Thankfully, renowned author, clinical nutritionist, and pharmacist James LaValle -- who operates at the cutting edge of longevity and rejuvenation science -- has invented an innovative dietary supplement that seems to help meet these needs.
The new offering combines two little-known ingredients that between them have powerful anti-inflammatory, antioxidant and anti-aging effects. It's called Synapsin.
Calorie Restriction Without Dieting
Long-time readers of this newsletter know that animals on a calorie-restricted diet stay healthier for longer, age more slowly and live longer. That’s why fasting has become a big thing among humans who want to extend their lives.Fasting improves health and adds years to life because a low calorie intake sends a signal to upregulate the activity of a family of proteins called sirtuins.
But sirtuins only function in the presence of NAD+. This coenzyme -- a form of vitamin B3 -- is found in all living cells and is at the heart of cellular metabolism, including energy production in the mitochondria. It's also believed to play important roles in the brain such as neurotransmission, learning and memory.
Trouble is, NAD+ gets depleted with aging. If a way could be found to boost NAD+, this would activate sirtuins and potentially maintain health and brain function -- and slow aging.
That's exactly what the first ingredient in Synapsin is able to do. It's called nicotinamide riboside (NR). Rodent studies found raising NAD+ made old mice less likely to suffer diabetes, improved mitochondria and liver function, and stopped the decline of adult stem cells that occurs with normal aging. Mice just plain lived longer with NR.1 A human study published earlier this year found middle-aged and older adults supplemented with NR enjoyed a whopping 60% boost in NAD+.2 But for an even greater boost, add a second nutrient. . .
Enhances Cognition and Memory
Among the family of ginsenosides found in Panax ginseng, one in particular stands out - Rg3, the partner of NR in Synapsin.Lab studies demonstrate Rg3’s wide-ranging brain health properties: enhances memory, improves cognition, dampens neuro-inflammation,3 reduces anxiety4 and depression,5 supports healthy neurotransmitter function, protects neurons from toxicity and reduces their death in neurodegenerative conditions,6 has antioxidant effects,7 and induces neurogenesis (new brain cells).8 Earlier this year researchers from State University of New York at Buffalo described Rg3 as a promising neuroprotective agent for the treatment of Alzheimer's.9
Repairs the Brain
Andrew Heyman, MD, Program Director of Integrative Medicine at George Washington University and owner of the Virginia Center for Health and Wellness in Northern Virginia has a lot of experience with NR and Rg3.He uses them to combat brain inflammation in patients suffering chronic stress, PTSD, Alzheimer's and Lyme disease. He describes the combination as "a fabulous, fabulous tool to begin that central nervous system repair process."10 Synapsin is available as a nasal spray, but requires a doctor's prescription. It is usually compounded with methylcobalamin, a highly absorbed form of vitamin B12, which itself protects brain cells and prevents brain shrinkage.
At a recent anti-aging conference, I heard doctors describe results that sounded miraculous to me.
Richmond Virginia compounding pharmacist Baylor Rice has been dispensing Synapsin for patients with Alzheimer's, Parkinson's, fibromyalgia, chronic fatigue syndrome, PTSD, concussion and autism. In his opinion, "If there's brain inflammation there, it's going to make a difference."11 But those in good health also use it to support focus, clarity, memory and overall neurological health.12
- https://endpoints.elysiumhealth.com/leonard-guarente-interview-901de12ae31
- https://www.ncbi.nlm.nih.gov/pubmed/29599478
- https://www.ncbi.nlm.nih.gov/pubmed/24244826
- https://www.ncbi.nlm.nih.gov/pubmed/16141527
- https://www.ncbi.nlm.nih.gov/pubmed/26528894
- https://www.ncbi.nlm.nih.gov/pubmed/18591781
- https://www.ncbi.nlm.nih.gov/pubmed/22310172
- https://www.ncbi.nlm.nih.gov/pubmed/17663584
- https://www.ncbi.nlm.nih.gov/pubmed/28697660
- https://www.youtube.com/watch?v=kVgU3rn_rsw
- https://www.wric.com/health/nasal-spray-synapsin-making-a-difference-with-various-illnesses/1193471412
- http://synapsinspray.com/
